Effect of lowering temperature in tissue and organ preservation Research Paper

Effect of lowering temperature in tissue and organ preservation - Research Paper Example Enzymes in tissues and organs dissociate through inactivation because of cold-related propensities. Some enzymes are intrinsically affected by cooling. Reducing the temperature increases trans-membrane diffusion of solutes from minute ions to expanded molecules (Fuller et al., 2014). Hypothermic Machine Perfusion Preservation This preservation method was developed to enhance the quality and time of preservation of kidneys. The method allows the movement of oxygen to the tissues to enable ATP synthesis. The perfusion of the fluids aids in the transportation of oxygen through the fluids to essential areas of the organ (In Kirk, 2014). The perfusion process is positively impacted when the temperatures are regulated to certain limits. Even though the reduction of temperatures can have certain side effects, the preservation viability is immensely enhanced. Oxygen Persufflation The method employs gaseous oxygen in improving the viability of an organ for transplant. For instance, oxygen is bubbled through a vasculature that is then released through minute proliferations at the organ's surface. The method is effective in liver preservation because of its homogenous distribution of oxygen. The method has incredible capabilities of recovering the DCD organs (In Kirk, 2014). The two methods are critical in reducing the metabolic and chemical reactions that can otherwise affect the normal establishment of an organ. The flow of oxygen within the organ is the principal foundation of employed by the methods of preserving organs and tissues.